August 29, 2020

Herba Centellae consists of the dried aerial parts or the entire plant of Centella ghortapre, gotu kola, gotukola, herba pegagan, herba kakikuda, hydrocotyle. Download Citation on ResearchGate | On Mar 25, , Islamiyah Neda Rahayu and others published UJI EFEK HEPATOPROTEKTIF INFUS HERBA. Mubarokah A. Uji efek sedatif ekstrak metanol herba pegagan (centella asiatica) terhadap mencit putih jantan dengan metode potensiasi.

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Herba Centellae consists of the dried aerial parts or the entire plant of Centella asiatica L. Apiaceae are also known as Umbelliferae.

A slender trailing herb, rooting at the nodes. Stems long, prostrate, emerging from the leaf-axils of a vertical rootstock, filiform, often reddish, with long internodes and rooting at the nodes; leaves thin, long-petioled, several from the rootstock and 1—3 from each node of the stems, 1.

Some parenchymatous cells contain crystals of calcium oxalate. Fruits, epidermis of polygonal cells, trichomes similar to the leaves, sheets of elongated parquetry layer cells, bundles of narrow annular vessels, and parenchymatous cells contain single large prisms of calcium oxalate 4.

It is especially abundant in the swampy areas of India, the Islamic Republic of Iran, Pakistan, and Sri Lanka up to an altitude of approximately m 146810 Macroscopic and microscopic examinations; and microchemical tests for the presence of triterpenes and reducing sugars 14.

The test for Salmonella spp. The maximum acceptable limits of other microorganisms are as follows 12— For preparation of decoction: Preparations for internal use: To be established in accordance with national requirements. Normally, the maximum residue limit of aldrin and dieldrin in Herba Centellae is not more than 0.

For other pesticides, see WHO guidelines on quality control methods for medicinal plants 12 and guidelines for predicting dietary intake of pesticide residues Recommended lead and cadmium levels are not more than 10 and 0. For analysis of strontium, iodine, caesium, caesium, and plutonium, see WHO guidelines on quality control methods for medicinal plants Chemical tests, and tests for drug interactions and moisture to be established by national authorities.

Determination of asiaticoside and related triterpene ester glycosides by thin-layer chromatography 16 and spectroscopic analysis The major principles in Herba Centellae are the triterpenes asiatic acid and madecassic acid, and their derived triterpene ester glycosides, asiaticoside and madecassoside 810 Dried drug for infusion 18 ; galenic preparations for oral administration Powder or extract liquid or ointment for topical application 14.

Package in well-closed, light-resistant containers. Treatment of wounds, burns, and ulcerous skin ailments, and prevention of keloid and hypertrophic scars 1018— Extracts of the plant have been employed to treat second- and third-degree burns Extracts have been used topically to accelerate healing, particularly in cases of chronic postsurgical and post-trauma wounds Extracts have been administered orally to treat stressinduced stomach and duodenal ulcers Herba Centellae is reported to be used in the treatment of leprous ulcers and venous disorders 56810 Studies suggest that extracts of Centella asiatica cause regression of inflammatory infiltration of the liver in cirrhosis patients 10 Further experimentation is needed to confirm these findings.


Therapy of albinism, anaemia, asthma, bronchitis, cellulite, cholera, measles, constipation, dermatitis, diarrhoea, dizziness, dysentery, dysmenorrhoea, dysuria, epistaxis, epilepsy, haematemesis, haemorrhoids, hepatitis, hypertension, jaundice, leukorrhoea, nephritis, nervous disorders, neuralgia, rheumatism, smallpox, syphilis, toothache, urethritis, and varices; and as an antipyretic, analgesic, anti-inflammatory, and “brain tonic” agent 457.

Poultices have been used to treat contusions, closed fractures, sprains, and furunculosis 7. The pharmacological activity of Centella asiatica is thought to be due to several saponin constituents, including asiaticoside, asiatic acid, and madecassic acid In vitroeach of these compounds stimulated the production of human collagen I, a protein involved in wound healing Stimulation of collagen synthesis in foreskin fibroblast monolayer cultures by an extract from Herba Centellae has also been reported Asiaticoside accelerated the healing of superficial postsurgical wounds and ulcers by accelerating cicatricial action Asiaticoside stimulates the epidermis by activating the cells of the malpighian layer in porcine skin, and by keratinization in vitro Topical application of asiaticoside promoted wound healing in rats and significantly increased the tensile strength of newly formed skin 21 Asiaticoside has been reported to decrease fibrosis in wounds, thus preventing new scar formation The mechanism of action appears to be twofold: It has further been proposed that asiaticoside interferes with scar formation by increasing the activity of myofibroblasts and immature collagen Extract of Herba Centellae effectively treated stress-induced stomach and duodenal ulcers in humans 10 Oral administration of C.

The mechanism of action appears to be associated with a central nervous system-depressant activity of C. In clinical trials, an extract of C. In an open clinical study, treatment of 20 patients with soiled wounds and chronic or recurrent atony with a galenical formulation containing Local application of an extract of the drug to second- and third-degree burns expedited healing, prevented pegagxn shrinking and swelling caused by infection, and further inhibited hypertrophic scar formation After 3 weeks of treatment, herbs of the patients were completely healed and the ulcer size in the remaining 5 patients was decreased Another trial using the same cream preparation demonstrated similar results A standardized extract of Herba Centellae was reported to treat ulcus cruris indolent leg ulcers effectively in clinical trials 34 In a double-blind study, no significant effect on healing was observed in patients with ulcus cruris after oral treatment with asiaticoside In a controlled study of 90 patients with perforated leg lesions owing to leprosy, application of a salve of the plant produced significantly better results than a placebo 1122 Clinical trials of the drug have demonstrated its antiulcer activity after oral pegaagn 2839 Fifteen patients with peptic or duodenal ulcer were treated with a titrated extract of Herba Centellae Clinical studies of Herba Centellae in the treatment of various venous disorders has demonstrated a positive therapeutic effect In patients suffering from venous insufficiency who were treated with a titrated extract of the drug, venous distension and oedema improved significantly, as compared with controls Asiaticoside has been implicated as a possible skin carcinogen in rodents after repeated topical application Further experimentation is needed to substantiate this claim.


Pegagan gajah – Wikipedia bahasa Indonesia, ensiklopedia bebas

No information was available concerning drug interactions, drug and laboratory test interactions, teratogenic or non-teratogenic effects on pregnancy, nursing mothers, or paediatric use. Allergic contact dermatitis has been associated with topical application of C. However, further testing revealed that these reactions may pegagqn due to other ingredients in the preparations African pharmacopoeia1st ed.

Materia medika IndonesiaJilid I.

Jakarta, Departemen Kesehatan, Republik Indonesia, The Indian pharmaceutical codex. British herbal pharmacopoeia, Part 2. London, British Herbal Medicine Association, Medicinal plants in Viet Nam.

Pharmacognosy9th ed. Medicinal plants of IndiaVol. Clinical applications of Centella asiatica L. Phoenix, AZ, Oryx Press, Farnsworth NR, Bunyapraphatsara N, eds.

WHO Monographs on Selected Medicinal Plants – Volume 1: Herba Centellae

Quality control methods for medicinal plant materials. Geneva, World Health Organization, Stuttgart, Deutscher Apotheker Verlag, Guidelines for predicting dietary intake of pesticide residues peggan, 2nd rev. Determination of asiaticoside contained in sanjinplan. Zhongguo yaoke daxue xuebao, Bolletin chimica farmacia, Martindalethe extra pharmacopoeia30th ed.

London, Pharmaceutical Press, Oxygen dressings and asiaticoside in the treatment of burns. Laval medicine, Bosse JP et al. Clinical study of a new antikeloid agent.

Pegagan gajah

Annals of plastic surgery, 3: Morisset R et al. Evaluation of the healing activity of Hydrocotyle tincture in the treatment of wounds.

Phytotherapy research, 1: Chaudhuri S et al. Pegzgan of common Indian herb Mandukaparni in the treatment of leprosy preliminary report. Journal of the Indian Medical Association, Darnis F et al. Use of a titrated extract of Centella asiatica in chronic hepatic disorders. Semaine hospitaux de Paris, Bonte F et al.

Influence of asiatic acid, madecassic acid, and asiaticoside on human collagen I synthesis. Planta medica,